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Leif Dehmelt

(PI;)

Project(s) involved: XX - Nalbant/Dehmelt

Vita
Education

2015
Habilitation “Cytoskeletal Mechanisms in Neurite Formation”, Department Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Germany and Faculty of Chemistry and Chemical Biology, TU Dortmund, Germany

2000
PhD thesis “Identification and Characterization of Na+/Phosphate Cotransporter Type II interacting proteins”
Department Epithelial Physiology, Max Planck Institute of Molecular Physiology, Germany and Faculty of Chemistry, TU Dortmund, Germany

1997
Diploma thesis “Expression and structural characterization of the potential regulatory protein IPAN”
Department Epithelial Physiology, Max Planck Institute of Molecular Physiology, Germany and Faculty of Chemistry, TU Dortmund, Germany


Current Positions

Since 2011
Group Leader, Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Germany

Since 2007
Group Leader, Faculty of Chemistry and Chemical Biology, TU Dortmund, Germany


Previous Positions

2000 – 2007
Research Associate, Department of Cell Biology, The Scripps Research Institute, USA

2000
Postdoctoral Practical,
Disease Group Cardiovascular, Aventis Pharma Deutschland GmbH, Germany


Fellowships and Awards

2015-2018
Marie Curie Innovative Training Network “InCeM: Integrated Component Cycling in Ephithelial Cell Motility”, Call: H2020-MSCA-ITN-2014; Project ID:642866, Associated Partner together with Perihan Nalbant, University Duisburg-Essen, Germany

2008-2014
FORSYS Young Investigator Group “Subsystem Interactions in Neuronal Development”, BMBF grant 0315258, Principal Investigator

2010-2013
Project grant "Cell migration and differentiation: Causalities in signal networks of Rho GTPases", MERCUR grant 2010-2022, together with Perihan Nalbant, University Duisburg-Essen, Germany, Principal Investigator

2003
Norton B. Gilula Travel Award for Best Oral Presentation, Department of Cell Biology, The Scripps Research Institute, USA

 

Forschung im Überblick

Zellformänderungen spielen in der Entwicklung und Funktion multizellulärer Organismen eine zentrale Rolle. Störungen in den Signalnetzwerken welche diese Prozesse steuern können Fehlentwicklungen oder Krebs induzieren. In unserer Arbeitsgruppe untersuchen wir, wie diese Signalnetzwerke die Form und Funktion von Zellen steuern. Wir beschäftigen uns insbesondere mit selbstorganisierenden Systemen, welche durch Kopplung von Reaktionen und Diffusion Aktivitätsmuster in einzelnen Zellen generieren können [1-3]. Um diese Systeme zu untersuchen, implementieren wir einen interdisziplinären Ansatz [4,5], der akute, Mikroskopie-basierte experimentelle Störungen, die Entwicklung neuer Analysetechnologien und mathematische Modellierung kombiniert.

 

Ausgewählte Publikationen

PubMed List>

[1] Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, Schulze N, Jungkurth JK, Patwardhan R, Solouk D, Hampe N, Hoffmann B, Dehmelt L, Nalbant P (2017). An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol 21(14):5311-6.
doi: 10.1083/jcb.201706052.

[2] Kamps D, Dehmelt L (2017). Deblurring Signal Network Dynamics. ACS Chem Biol 12(9):2231-2239.
doi: 10.1021/acschembio.7b00451.

[3] Dehmelt L, Bastiaens PI (2010). Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol 11(6):440-52.
doi: 10.1038/nrm2903.

[4] Chen X, Venkatachalapathy M, Kamps D, Weigel S, Kumar R, Orlich M, Garrecht R, Hirtz M, Niemeyer CM, Wu YW, Dehmelt L. (2017). "Molecular-Activity Painting": Switch-like, Light-Controlled Perturbations inside Living Cells. Angew Chem Int Ed Engl 21(14):5311-6.
doi: 10.1002/anie.201611432

[5] Gandor S, Reisewitz S, Venkatachalapathy M, Arrabito G, Reibner M, Schröder H, Ruf K, Niemeyer CM, Bastiaens PI, Dehmelt L (2013). A protein-interaction array inside a living cell. Angew Chem Int Ed Engl 52(18):4790-4.
doi: 10.1002/anie.201209127.