All Publications from the SPP1926

2021

Burak Bali, David Lopez de la Morena, Artur Mittring, Thomas Mager, Vladan Rankovic, Antoine Tarquin Huet, Tobias Moser. (2021) Utility of red?light ultrafast optogenetic stimulation of the auditory pathway. EMBO molecular medicine 13 (6), e13391

Gao L, J Meiring, C Heise, A Rai, A Müller-Deku, A Akhmanova, J Thorn-Seshold, and O Thorn-Seshold. (2021) Photoswitchable epothilone-based microtubule stabilisers allow GFP-imaging-compatible, optical control over the microtubule cytoskeleton. Angewandte Chemie 2021https://doi.org/10.1002/anie.202114614

Gao L, J Meiring, Y Kraus, M Wranik, T Weinert, S Pritzl, R Bingham, E Ntouliou, K Jansen, N Olieric, J Standfüss, L Kapitein, T Lohmüller, J Ahlfeld, A Akhmanova, M Steinmetz, and O Thorn-Seshold (2021) A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton. Cell Chemical Biology 2021, 28, 1https://doi.org/10.1016/j.chembiol.2020.11.007

AT Huet, T Dombrowski, V Rankovic, A Thirumalai, T Moser. (2021) Developing Fast, Red-Light Optogenetic Stimulation of Spiral Ganglion Neurons for Future Optical Cochlear Implants. Frontiers in Molecular Neuroscience 14, 13

Imambocus, B. N., F. Zhou, A. Formozov, A. Wittich, F. M. Tenedini, C. Hu, K. Sauter, E. Macarenhas Varela, F. Heredia, A. P. Casimiro, A. Macedo, P. Schlegel, C. H. Yang, I. Miguel-Aliaga, J. S. Wiegert, M. J. Pankratz, A. M. Gontijo, A. Cardona and P. Soba (2021). "A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae." Curr Biol doi.org/10.1016/j.cub.2021.10.069

Kueck NA, Ovcharenko A, Hartstock K, Cornelissen NV, Rentmeister A: Chapter Eight - Chemoenzymatic labeling of RNA to enrich, detect and identify methyltransferase-target sites. In Methods in Enzymology. Edited by Jackman JE: Academic Press; 2021:161-190. vol 658.

Mahn M, Saraf-Sinik I, Patil P, Pulin M, Bitton E, Karalis N, Bruentgens F, Palgi S, Gat A, Dine J, Wietek J, Davidi I, Levy R, Litvin A, Zhou F, Sauter K, Soba P, Schmitz D, Lüthi A, Rost BR, Wiegert JS, Yizhar O. (2021) Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin. Neuron 109(10):1621-1635.e8. doi: 10.1016/j.neuron.2021.03.013. Epub 2021 May 11. PMID: 33979634

Mattay J, Dittmar M, Rentmeister A: Chemoenzymatic strategies for RNA modification and labeling. Current Opinion in Chemical Biology 2021, 63:46-56.

Michailidou F, Klöcker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A: Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angewandte Chemie International Edition 2021, 60:480-485.

Mullenbroich MC, Kelly A, Acker C, Bub G, Bruegmann T, Di Bona A, Entcheva E, Ferrantini C, Kohl P, Lehnart SE, Mongillo M, Parmeggiani C, Richter C, Sasse P, Zaglia T, Sacconi L, Smith GL (2021) Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review. Front Physiol  12: 769586.

Oldani S, Moreno-Velasquez L, Faiss L, Stumpf A, Rosenmund C, Schmitz D, Rost BR. (2021) SynaptoPAC, an optogenetic tool for induction of presynaptic plasticity. J Neurochem 156(3): 324-336. doi: 10.1111/jnc.15210. Epub 2020 Oct 22. PMID: 33037623

Ovcharenko A, Weissenboeck FP, Rentmeister A: Tag-Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases. Angew Chem Int Ed 2021, 60:4098-4103.

Reichert D, Mootz HD, Rentmeister A: Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1. Chemical Science 2021, 12:4383-4388.

Sailer A, J Meiring, C Heise, L Pettersson, A Akhmanova, J Thorn-Seshold, and O Thorn-Seshold (2021) Pyrrole hemithioindigo antimitotics with near-quantitative bidirectional photoswitching photocontrol cellular microtubule dynamics with single-cell precision. Angewandte Chemie 2021, 60, 23695http://dx.doi.org/10.1002/anie.202104794

Sokolovski, Serge G.; Zherebtsov, Evgeny A.; Kar, Rajiv K.; Golonka, David; Stabel, Robert; Chichkov, Nikolai B.; Gorodetsky, Andrey; Schapiro, Igor; Möglich, Andreas; Rafailov, Edik U. (2021) Two-Photon Conversion of a Bacterial Phytochrome. Biophysical Journal 120(5): 964-974. doi:10.1016/j.bpj.2021.01.028

12(1): 4527.

Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R (2021) Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Theranostics  11: 5569-5584.

Wegener JW, Wagdi A, Wagner E, Katschinski DM, Hasenfuss G, Bruegmann T, Lehnart SE (2021) The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool. Front Physiol  12: 777770.

Yang, W., M. Chini, J. A. Popplau, A. Formozov, A. Dieter, P. Piechocinski, C. Rais, F. Morellini, O. Sporns, I. L. Hanganu-Opatz and J. S. Wiegert (2021). "Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation." PLoS Biol 19(4): e3001146.

Yuan Wahlgren, Weixiao; Golonka, David; Westenhoff, Sebastian; Möglich, Andreas. (2021). Cryo-electron microscopy of Arabidopsis thaliana phytochrome A in its Pr state reveals head-to-. Frontiers in Plant Science 12. doi:10.3389/fpls.2021.663751

2020

Funken M, Bruegmann T, Sasse P (2020) Selective optogenetic stimulation of fibroblasts enables quantification of hetero-cellular coupling to cardiomyocytes in a three-dimensional model of heart tissue. Europace  22: 1590-1599.

Golonka, David; Gerken, Uwe; Köhler, Jürgen; Möglich, Andreas. (2020). The Association Kinetics Encode the Light Dependence of Arabidopsis Phytochrome B Interactions. Journal of Molecular Biology. doi:10.1016/j.jmb.2020.06.001

Klocker N, Weissenboeck FP, Rentmeister A: Covalent labeling of nucleic acids. Chem Soc Rev 2020, 49:8749-8773.

Müller-Deku A, J Meiring, K Loy, Y Kraus, C Heise, R Bingham, K Jansen, X Qu, F Bartolini, L Kapitein, A Akhmanova, J Ahlfeld, D Trauner*, O Thorn-Seshold*; Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton. Nature Communications 2020, 11, 4640.

Pilsl, Sebastian; Morgan, Charles; Choukeife, Moujab; Möglich, Andreas; Mayer, Günter. (2020) Optoribogenetic control of regulatory RNA molecules. Nature Communications 11: 4825. doi:10.1038/s41467-020-18673-5

Renzl C, Kakoti A, Mayer G. (2020). Aptamer-Mediated Reversible Transactivation of Gene Expression by Light. Angew Chem Int Ed Engl. 59(50): 22414-22418. doi: 10.1002/anie.202009240.

Perez-Alvarez, A., B. C. Fearey, R. J. O'Toole, W. Yang, I. Arganda-Carreras, P. J. Lamothe-Molina, B. Moeyaert, M. A. Mohr, L. C. Panzera, C. Schulze, E. R. Schreiter, J. S. Wiegert, C. E. Gee, M. B. Hoppa and T. G. Oertner (2020). "Freeze-frame imaging of synaptic activity using SynTagMA." Nat Commun 11(1): 2464.

Westerich KJ, Chandrasekaran KS, Gross-Thebing T, Kueck N, Raz E, Rentmeister A: Bioorthogonal mRNA labeling at the poly(A) tail for imaging localization and dynamics in live zebrafish embryos. Chemical Science 2020, 11:3089-3095.

2019

Azimi Hashemi N*, Bergs ACF*, Schüler C, Scheiwe AR, Steuer Costa W, Bach M, Liewald JF, Gottschalk A. (2019) Rhodopsin-based voltage imaging tools for use in muscles and neurons of Caenorhabditis elegans. PNAS 116: 17051-60. doi: 10.1073/pnas.1902443116.

Binder, S., M. Molle, M. Lippert, R. Bruder, S. Aksamaz, F. Ohl, J. S. Wiegert and L. Marshall (2019). "Monosynaptic Hippocampal-Prefrontal Projections Contribute to Spatial Memory Consolidation in Mice." J Neurosci 39(35): 6978-6991.

Durst, C. D., J. S. Wiegert, N. Helassa, S. Kerruth, C. Coates, C. Schulze, M. A. Geeves, K. Torok and T. G. Oertner (2019). "High-speed imaging of glutamate release with genetically encoded sensors." Nat Protoc 14(5): 1401-1424.

Golonka, David; Fischbach, Patrick; Jena, Siddhartha G.; Kleeberg, Julius R. W.; Essen, Lars-Oliver; Toettcher, Jared E.; Zurbriggen, Matias D.; Möglich, Andreas. (2019). Deconstructing and repurposing the light-regulated interplay between Arabidopsis phytochromes a. Communications Biology 2. doi:10.1038/s42003-019-0687-9

Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. (2019) A photoactivatable botulinum toxin for inducible control of neurotransmission. Neuron 101: 863-875. doi: 10.1016/j.neuron.2019.01.002.

Makowka,P., Bruegmann, T., Dusend, V., Malan, D. ,Beiert, T., Hesse, M., Fleischmann, B.K., Sasse, P. Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision. (2019). Nature Communications 10: 1281.

Oppermann, J., P. Fischer, A. Silapetere, B. Liepe, S. Rodriguez-Rozada, J. Flores-Uribe, E. Peter, A. Keidel, J. Vierock, J. Kaufmann, M. Broser, M. Luck, F. Bartl, P. Hildebrandt, J. S. Wiegert, O. Beja, P. Hegemann and J. Wietek (2019). "MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins." Nat Commun 10(1): 3315.

Weber, Anna M.; Kaiser, Jennifer; Ziegler, Thea; Pilsl, Sebastian; Renzl, Christian; Sixt, Lisa; Pietruschka, Georg; Moniot, Sébastien; Kakoti, Ankana; Juraschitz, Marc; Schrottke, Stefanie; Lledo Bryant, Laura; Steegborn, Clemens; Bittl, Robert; Mayer, Günter; Möglich, Andreas. (2019). A blue light receptor that mediates RNA binding and translational regulation. Nature Chemical Biology. doi:10.1038/s41589-019-0346-y

Woldemariam S, Nagpal J, Hill T, Li J, Schneider M, Shankar R, Futey M, Varshney A, Ali N, Mitchell J, Andersen K, Barsi-Rhyne B, Tran A, Steuer Costa W, Krzyzanowski M, Yu Y, Brueggemann C, Hamilton S, Ferkey D, VanHoven M, Sengupta P, Gottschalk A, L'Etoile N. (2019) Robust and sensitive GFP-based cGMP sensor for real time imaging in intact Caenorhabditis elegans. Genetics 213: 59-77. doi: 10.1534/genetics.119.302392.

 

2018

Alberio, L., Kukovetz, K. Thiel, G, Moroni, A (2018). A light-gated K+ channel for sustained neuronal inhibition in freely moving animals. Nat Methods 15: 969-976

Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. (2018). Sci Rep 8: 15024. DOI: 10.1038/s41598-018-32929-7

Balbach M, Beckert V, Hansen JN, Wachten D. Shedding light on the role of cAMP in mammalian sperm physiology. (2018). Mol Cell Endocrinol 468: 111-120

Bergs ACF, Schultheis C, Fischer E, Tsunoda SP, Erbguth K, Husson SJ, Govorunova E, Spudich JL, Nagel G, Gottschalk A, Liewald JF. (2018) Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans. PLoS ONE 13(2): e0191802. doi: 10.1371/journal.pone.0191802

Bernal Sierra YA*, Rost BR*, Pofahl M*, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bönigk W, Kohl P, Baier H, Schneider-Warme F, Hegemann P, Beck H, Seifert R, Schmitz D (2018). Potassium channel-based optogenetic silencing. Nat Commun 9: 4611. doi: 10.1038/s41467-018-07038-8. (*co-first authors)

Brown J, Behnam R, Coddington L, Tervo DGR, Martin K, Proskurin M, Kuleshova E, Park J, Phillips J, Bergs ACF, Gottschalk A, Dudman JT, Karpova AY. (2018) Expanding the Optogenetics Toolkit by Topological Inversion of Rhodopsins. Cell 175: 1131-1140. doi: 10.1016/j.cell.2018.09.026

Chatelle C, Ochoa-Fernandez R, Engesser R, Schneider N, Beyer HM, Jones A, Timmer J, Zurbriggen MD*, Weber W*  A green light-responsive system for the control of transgene expression in mammalian and plant cells. (2018). ACS Synth Biol 7: 1349-1358. DOI: 10.1021/acssynbio.7b00450

Di Ventura B, Mootz HD. Switchable inteins for conditional protein splicing. (2018) Biol Chem. doi: 10.1515/hsz-2018-0309.

Falk T, Mai D, Bensch R, Cicek Ö, Abdulkadir A, Marrakchi Y, Böhm A, Deubner J, Jäckel Z, Seiwald K, Dovzhenko A, Tietz O, Dal Bosco C, Walsh S, Saltukoglu D, Tay T, Prinz M, Palme K, Simons M, Diester I, Brox T, Ronneberger O (2018). Deep Learning for Cell Counting, Detection, and Morphometry. Nat Methods, accepted.

Fosrster D, Kramer A, Baier H, Kubo F. Optogenetic precision toolkit to reveal form, function and connectivity of single neurons. (2018). Methods 150: 42-48.

Grimm C, Silapetere A, Vogt A, Bernal Sierra YA, Hegemann P Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2. (2018). Sci Rep 8: 9316. doi: 10.1038/s41598-018-27690-w.

Helassa N, Durst CD, Coates C, Kerruth S, Arif U, Schulze C, Wiegert JS, Geeves M, Oertner TG, Torok K (2018). Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses. PNAS 115: 5594.

Lutz AP, Schladebeck S, Renicke C, Spadaccini R, Mösch HU, Taxis C. Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast. (2018). Genetics. 209: 157-171. doi: 10.1534/genetics.118.300744.

Mark MD, Donner M, Eickelbeck D, Stepien J, Nowrousian M, Kück U, Paris F, Hellinger J, Herlitze S Visual tuning in the flashlight fish Anomalops katoptron to detect blue, bioluminescent light. (2018). PLoS One 13: e0198765

Nagpal J, Herget U, Choi MK, Ryu S. Anatomy, development, and plasticity of the neurosecretory hypothalamus in zebrafish. (2018). Cell Tissue Res. doi: 10.1007/s00441-018-2900-4.

Oda K, Vierock J, Oishi S, Rodriguez-Rozada S, Taniguchi R, Yamashita K, Wiegert JS, Nishizawa T*, Hegemann P*, Nureki O* (2018). Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun 9: 3949 (*corresponding authors)

Schneider-Warme F  The power of optogenetics: Potential in cardiac experimental and clinical electrophysiology. (2018). Herzschrittmacher-ther Elektrophysiol 29: 24-29.

Schneider-Warme F, Johnston CM, Kohl P  Organotypic myocardial slices as model system to study heterocellular interactions. (2018). Cardiovasc Res 114: 3-6

Schneider-Warme F, Ravens. Using light to fight atrial fibrillation. (2018). Cardiovasc Res 114: 635–637.

Stumpf A, Parthier D, Sammons RP, Stempel AV, Breustedt J, Rost BR, Schmitz D. Cannabinoid type 2 receptors mediate a cell type-specific self-inhibition in cortical neurons. (2018). Neuropharmacol 139: 217-225. doi: 10.1016/j.neuropharm.2018.07.020.

Wiegert JS, Pulin M, Gee CE, Oertner TG (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife 7: e39151

Wozny C, Beed P, Nitzan N, Pössnecker Y, Rost BR, Schmitz D VGLUT2 Functions as a Differential Marker for Hippocampal Output Neurons. (2018). Front Cell Neurosci 12: 337. doi: 10.3389/fncel.2018.00337.

2017

Berger TK, Fusshöller DM, Goodwin N, Bönigk W, Müller A, Dokani Khesroshahi N, Brenker C, Wachten D, Krause E, Kaupp UB, Strünker T  Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating. (2017) J Physiol 595: 1533-46

Bitzenhofer SH, Ahlbeck J, Wolff A, Wiegert JS, Gee CE, Oertner TG, Hanganu-Opatz IL (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Commun 8:14563.

Fischer E, Gottschalk A, Schueler C (2017) An optogenetic arrhythmia model to study catecholaminergic polymorphic ventricular tachycardia mutations. Sci. Rep. 7: 17514. DOI:10.1038/s41598-017-17819-8

Hardung S, Alyahyay M, Eriksson D, Diester I. A Toolbox for Optophysiological Experiments in Freely Moving Rats. (2017) Front Syst Neurosci, 11: 27. doi: 10.3389/fnsys.2017.00027.

Hardung S, Epple R, Jackel Z, Eriksson D, Uran C, Senn V, Gibor L, Yizhar O, Diester I (2017). A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition. Curr Biol 27: 549-55.

Hasegawa E, Maejima T, Yoshida T, Masseck O, Herlitze S, Yoshioka M, Sakurai T, Mieda M (2017). Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity. PNAS 114: E3526-E3535

Hu C, Petersen M, Hoyer N, Spitzweck B, Tenedini F, Wang D, Gruschka A, Burchardt LS, Szpotowicz E, Schweizer M, Guntur AR, Yang C-H, Soba P (2017). Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior Nat Neuroscience 20: 1085–1095.

Jansen V, Jikeli JF, Wachten D. How to control cyclic nucleotide signaling by light. (2017) Curr Opin Biotechnol 48: 15-20.

Johnston CM, Rog-Zielinska EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Schneider-Warme F  Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility. (2017). Prog Biophys Mol Biol 130(Pt B): 140-149

Rost BR, Schneider-Warme F, Schmitz D, Hegemann P (2017). Optogenetic Tools for Subcellular Applications in Neuroscience. Neuron 96: 572-603. doi: 10.1016/j.neuron.2017.09.047.

Soya S, Takahashi T, McHugh T, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T (2017). Orexin modulates behavioral fear expression through the locus coeruleus. Nat Commun 8: 1606

Wachten D, Jikeli JF, Kaupp UB. Sperm Sensory Signaling. (2017) Cold Spring Harb Pers-pect Biol 9: a028225. doi: 10.1101/cshperspect.a028225.

Wiegert JS, Mahn M, Prigge M, Printz Y, Yizhar O (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95: 504-529.

Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG, Soba P, Hegemann P, Wiegert JS (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep. 7: 14957. doi: 10.1038/s41598-017-14330-y.

2016

Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D (2016). A novel biosensor to study cAMP dynamics in cilia and flagella. eLife 5: e14052. doi: 10.7554/eLife.14052

Spoida K, Eickelbeck D, Karapinar R, Eckhardt T, Mark MD, Jancke D, Ehinger B, König P, Dalkara D, Herlitze S, Masseck OA (2016). Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways. Curr Biol 26: 1206-12.